兵荒马乱的战国时代，一个被安加了“霸星”宿命的小女孩在楚威王（赵文瑄 饰）的宫殿中诞生了。作为一代霸主，楚威王渴望雄霸天下，他对这个可爱的女儿芈月（刘楚恬 饰）也疼爱有加。然而后宫之争阴谋难测，当大王永眠黄泉之际，芈月的人生也进入了凶险的境地。躲过了死亡的威胁，亭亭玉立的芈月（孙俪 饰）以媵人的身份随同芈姝（刘涛 饰）嫁给秦王赢驷（方中信 饰）。在此过程中，屈原、黄歇、张仪、苏秦、白起、商鞅、公孙衍、司马错等风云人物相继登场，他们纵横捭阖，攻城拔寨，一个字的才学和武功左右着战国的格局。 而在这一巨大的漩涡中，身处后宫纷争的芈月将以她柔弱女子的力量，书写着一代女后的千古传奇……
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